Pharmaceutical Products

Alecensa is an oral medicine, used for the treatment of people with non-small cell lung cancer (NSCLC) whose tumours are identified as anaplastic lymphoma kinase (ALK)-positive.

Alecensa contains the active substance alectinib and it belongs to a group of drugs called small molecule kinase inhibitors.

Alecensa blocks the action of an enzyme called ‘ALK tyrosine kinase’. Abnormal forms of this enzyme help to encourage cancer cell growth.

Patient Information Leaflet

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet- Alecensa 150mg hard capsules

Avastin was the first anti-angiogenic therapy for the treatment of patients with metastatic colorectal, ovarian, breast, renal cell or non-small cell lung cancer.

Avastin is an intravenous anti-angiogenic therapy that contains the active substance bevacizumab. It belongs to a group of medicines called monoclonal antibodies.

A monoclonal antibody is a type of protein designed to attach to a specific target in the body made by the immune system to help defend the body from infection and cancer. These therapies stop the process of developing new blood vessels in cancer tumours (angiogenesis).

Avastin is used for the treatment of advanced stages of breast, colorectal, non-small cell lung, kidney, ovarian and cervical cancers. 

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Avastin 25mg/ml concentrate for solution for infusion.

CellCept is used in the prevention of organ rejection in patients receiving kidney, heart, or liver transplants.

CellCept is an oral immunosuppressant therapy that contains the active agreement mycophenolate mofetil. CellCept works by reducing the activity of the body's immune system. 

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Cellcept 250mg Capsules

Patient Information Leaflet - Cellcept 500mg powder for concentrate for solution for infusion
Patient Information Leaflet - Cellcept 500mg Film-coated Tablets
Patient Information Leaflet - Cellcept 1g/5ml Powder for Oral Suspension

Cotellic is indicated for use in combination with vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.

Cotellic contains the active agreement cobimetinib. It belongs to a group of drugs called small molecule kinase inhibitors and the drug belongs to a family of tyrosine kinase inhibitors.  

Cotellic is an oral drug used in combination with another drug vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.

Patient Information Leaflet (PIL)

This link will take you to the www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Cotellic 20 mg film-coated tablets

Enspryng is a medicine for the treatment of neuromyelitis optica spectrum disorders (NMOSD) in adults and young people from 12 years of age.

Enspryng contains the active substance satralizumab, which is a type of protein called a monoclonal antibody. Monoclonal antibodies are designed to recognise and attach to a specific substance in the body.

Enspryng blocks the action of a protein called interleukin-6 (IL-6), which is involved in the processes that lead to damage and swelling in the nervous system. By blocking its effects, Enspryng reduces the risk of a relapse or attack of NMOSD.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Enspryng 120 mg solution for injection in pre-filled syringe

Esbriet is an oral medicine approved for the treatment of Idiopathic Pulmonary Fibrosis (IPF) and is available in approximately 40 countries worldwide.

Esbriet is an oral tablet with an active ingredient pirfenidone. Pirfenidone is an anti-fibrotic drug used for the treatment of mild to moderate idiopathic pulmonary fibrosis.  

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Esbriet 267 mg, 534 mg and 801 mg Film-coated Tablets

Erivedge is for the treatment of adult patients with advanced based cell carcinoma.

Erivedge is an anticancer medicine that contains the active substance Vismodegib. It belongs to a group of drugs called small molecule kinase inhibitors.

Erivedge is an anti-cancer medicine that works that works by controlling one of the key proteins involved in basal cell carcinoma. This may slow down or stop the growth of the cancer cells, or may kill them.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Erivedge 150 mg hard capsules

Evrysdi is a medicine for the treatment of spinal muscular atrophy (SMA) that contains the active substances risdiplam. It is used to treat patients with SMA Type 1, Type 2 or Type 3 or with one to four SMN2 copies from the age of two months.

Evrysdi works by helping the body produce more survival motor neuron (SMN) protein. Which prevents the loss of motor neurons and may improve how well muscles work in people with SMA.

Patient Information Leaflet (PIL):

This link will take you to www.medicines.ie, which is a non-Roche website.

Patient Information Leaflet – Evrysdi 0.75 mg/mL powder for oral solution

Gazyvaro is for the treatment of patients with Chronic Lymphocytic Leukaemia (CLL), the common form of Leukaemia and Follicular Lymphoma (FL).

Gazyvaro contains the active ingredient obinutuzumab. It belongs to a group of medicines called monoclonal antibodies. A monoclonal antibody is a type of protein designed to recognise and attach to a specific target in the body made by the immune system to help defend the body from infection and cancer.

Gazyvaro is approved as an intravenous drug in combination with chlorambucil for the treatment of patients with previously untreated chronic lymphocytic leukaemia. Gazyvaro in combination with chemotherapy, followed by Gazyvaro maintenance therapy in patients achieving a response, is indicated for the treatment of patients with previously untreated advanced follicular lymphoma (FL).

Gazyvaro in combination with bendamustine followed by Gazyvaro maintenance is indicated for the treatment of patients with follicular lymphoma (FL) who did not respond or who progressed during or up to 6 months after treatment with rituximab or a rituximab-containing regimen.

 

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Gazyvaro 1,000 mg concentrate for solution for infusion

Hemlibra is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children with haemophilia A with factor VIII inhibitors or severe haemophilia A without inhibitors. It is given as an injection under the skin (subcutaneous injection).

 

Haemophilia A is a bleeding condition people can be born with where a missing or faulty blood clotting factor (factor VIII) prevents blood from clotting normally.

 

Hemlibra is a therapeutic antibody that bridges clotting factors to help the blood clot. Like factor VIII, HEMLIBRA binds to factor IXa and factor X and mimics the effect of factor VIII in the body. It links factor IXa and factor X, and the clotting pathway can continue.

 

HEMLIBRA is not the same as factor VIII replacement therapy, so it is not thought that factor VIII inhibitors will affect HEMLIBRA.

 

Hemlibra is not a cure for haemophilia.

 

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Hemlibra 150 mg/mL Solution for Injection

Patient Information Leaflet - Hemlibra 30 mg/mL Solution for Injection

Herceptin is for the treatment of HER2 positive breast or gastric cancer.

Herceptin contains the active ingredient trastuzumab and is classed as humanised monoclonal. It belongs to a group of medicines called monoclonal antibodies. A monoclonal antibody is a type of protein designed to recognise and attach to a specific target in the body made by the immune system to help defend the body from infection and cancer.

Herceptin is an antibody directed against a cell surface protein produced by the human epidermal growth factor receptor 2 (HER2) gene. HER2 protein is overexpressed in about one-third of all breast cancers.

Herceptin (trastuzumab) is used in the treatment of breast cancer with such characteristics. It is also used with combination chemotherapy in HER2-positive metastatic gastric cancer. Herceptin is an intravenous and subcutaneous used to treat early and advanced breast and gastric cancer.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Herceptin 150mg Powder for concentrate for solution for infusion

Patient Information Leaflet - Herceptin 600 mg Solution for Injection in Vial

Kadcyla is the first antibody drug conjugate used for the treatment of patients with HER2 positive early breast cancer who have residual invasive disease after surgery or unresectable locally advanced or metastatic breast cancer.

Kadcyla contains the active substance trastuzumab emtansine, an antibody drug conjugate which is made up of two parts that are linked together:

trastuzumab - a monoclonal antibody that binds selectively to an antigen (a target protein) called human epidermal growth factor receptor 2 (HER2). HER2 is found in large amounts on the surface of some cancer cells where it stimulates their growth. When trastuzumab binds to HER2 it can stop the cancer cells growth and cause them to die.

DM1 – an anti-cancer substance that becomes active once Kadcyla enters the cancer cell. Kadcyla is administered as an intravenous (IV) infusion

 

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Kadcyla 100mg & 160mg powder for concentrate for solution for infusion

MabThera (rituximab) may be used for the treatment of several different conditions in adults: Non-Hodgkin’s Lymphoma (NHL); chronic lymphocytic leukaemia (CLL); rheumatoid arthritis; severe, active granulomatosis with polyangiitis (Wegener’s) (GPA) or microscopic polyangiitis (MPA) and moderate to severe pemphigus vulgaris (PV). In children and adolescents, MabThera, in combination with chemotherapy, can be used for the treatment of some types of NHL and, in combination with corticosteroids, for the treatment of GPA and MPA.

MabThera is a humanised monoclonal antibody it contains the active ingredient Mabthera and it belongs to a group of medicines called monoclonal antibodies. Mabthera sticks to the surface of a type of white blood cell called "B-Lymphocyte". When Mabthera sticks to the surface of this cell, the cell dies.

MabThera is available as an intravenous (IV) and subcutaneous (SC) therapy.

In adults the IV formulation of MabThera is used for the treatment of Non-Hodgkin’s Lymphoma, chronic lymphocytic leukaemia, rheumatoid arthritis; severe, active granulomatosis with polyangiitis or microscopic polyangiitis (Wegener’s) and moderate to severe pemphigus vulgaris.

The IV formulation of MabThera can be used to treat to children and adolescents, from 6 months of age and older, with non-Hodgkin’s lymphoma, specifically CD20 positive diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL)/Burkitt leukaemia (mature B-cell acute leukaemia) (BAL) or Burkitt-like lymphoma (BLL).

The IV formulation of MabThera can also be used for treat children and adolescents, from 2 years of age and older, with granulomatosis with polyangiitis (formerly called Wegener’s granulomatosis) or microscopic polyangiitis.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - MabThera 100 mg and 500 mg concentrate for solution for infusion

Patient Information Leaflet - MabThera 1400 mg Solution for Subcutaneous Injection

Madopar works on the central nervous system in the treatment of Parkinson’s disease and restless leg syndrome.

Madopar is an oral tablet contains the active ingredients of levodopa and benserazide. It belongs to a group of medicines called antiparkinsonian agents and is used for the treatment of patients with Parkinson’s disease and restless leg syndrome.  

Madopar works on the central nervous system. Parkinson disease inhibits dopamine levels in certain parts of the brain. This can result in slow movements stiff muscles and tremor. In the body levodopa is changed into dopamine. Dopamine is the active medicine that is needed in your brain to help Parkinson’s disease.

The benserazide allows more of the levodopa you take to get into your brain before it is changed into dopamine.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Madopar 200 mg/50 mg Hard Capsules
Patient Information Leaflet - Madopar 50 mg/12.5 mg, 100 mg/25 mg Dispersible Tablets

NeoRecormon is used to treat patients with symptomatic anaemia associated with chronic kidney disease (CKD) and to treat chemotherapy-related anaemia in cancer patients.

 

NeoRecormon is a clear, colourless solution for injection under the skin (subcutaneously) or into a vein (intravenously).It contains a hormone called epoetin beta, which stimulates the production of red blood cells.

 

Epoetin beta is produced by a specialised genetic technology and works in exactly the same way as the natural hormone erythropoietin. NeoRecormon is used to treat patients with symptomatic anaemia associated with chronic kidney disease (CKD) and to treat chemotherapy-related anaemia in cancer patients.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - NeoRecormon solution for injection Pre-Filled Syringe.

Ocrevus (ocrelizumab) is licensed to treat relapsing forms of Multiple Sclerosis (RMS) and early Primary Progressive Multiple Sclerosis (PPMS) in adults. It is the first and only medicine approved in the European Union to treat PPMS, a debilitating form of MS in which patients can experience rapidly worsening and irreversible disability.

 

MS affects approximately 700,000 patients in Europe, of which around 96,000 are diagnosed with PPMS.  Most patients with MS have either RMS or PPMS at diagnosis.

 

Ocrevus (ocrelizumab) belongs to a group of medicines called monoclonal antibodies. A monoclonal antibody is a type of protein designed to recognise and attach to certain cells in the human body.

 

Ocrevus (ocrelizumab) targets a certain type of immune cell (CD20-positive B cells). These B cells are believed to contribute to the damage to nerve cells and the nerve cell insulation (myelin). This nerve cell damage can lead to relapses and disability in patients with MS.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Ocrevus 300 mg concentrate for solution for infusion

Perjeta is for the treatment of HER2 positive early and metastatic breast cancer. It is a first in class HER2 dimerisation inhibitor designed to work synergistically with Herceptin and chemotherapy.

 

Perjeta contains the active ingredient Pertuzumab and is classed as humanised monoclonal. It belongs to a group of medicines called monoclonal antibodies. A monoclonal antibody is a type of protein designed to recognise and attach to a specific target in the body made by the immune system to help defend the body from infection and cancer.

 

Perjeta is designed to prevent the HER2 receptor from pairing with other HER receptors on the surface of cells, a mechanism that is complementary to another drug called Herceptin.

Perjeta is approved in combination with Herceptin for the treatment of patients with previously untreated HER2-positive metastatic breast cancer. 

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Perjeta 420 mg Concentrate for Solution for Infusion

Phesgo is a cancer medicine that contains two active substances: pertuzumab and trastuzumab. It is used to treat adult patients with “HER2-positive” breast cancer.

The two active substance of Phesgo, pertuzumab and trastuzumab are ‘monoclonal antibodies. They are designed to attach to a specific target on cells called “human epidermal growth factor receptor 2” (HER2). Which is found in large amounts on the surface of some cancer cells and stimulates their growth. By attaching to HER2 on cancer cells, pertuzumab and trastuzumab slow down thier growth, or kill them.

Usually pertuzumab and trastuzumab are given sequentially. Phesgo as a single treatment administers both pertuzumab and trastuzumab simultaneously.

Patient Information Leaflet (PIL)
This link will take you to www.medicines.ie, which is a non-Roche website.

Patient Information Leaflet - Phesgo 600mg/600mg and 1200mg/600mg solution for injection

Polivy is a cancer medicine used to treat adults with diffuse large B-cell lymphoma (DLBCL) whose cancer has returned after responding to previous treatment (relapsed DLBCL) or has not responded to previous treatment (refractory DLBCL) and who cannot have a bone-marrow transplantation. It is used in combination with two other cancer treatments: bendamustine and rituximab product.

 

DLBCL is a type of aggressive lymphoma that affects B cells. B cells are white blood cells that protect your body from infection.

 

Polivy is a type of medicine called an antibody-drug conjugate, or ADC. Polivy is designed to work differently from traditional chemotherapies because it has the ability to find dividing B cells, including cancerous B cells.

 

Almost all B cells (including cancerous ones) have a marker on their surface called CD79b. Polivy works by finding and attaching to B cells using the CD79b marker before entering the cell and releasing an anti-cancer drug, killing the B cell. Polivy may also harm healthy cells in the body. A full list of side effects reported with this medicine can be found in the Patient Information Leaflet.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Polivy 30 mg and 140 mg powder for concentrate for solution for infusion

Pulmozyme is used in the treatment of people with cystic fibrosis.

 

Pulmozyme is a nebulizer inhaled medication with active ingredient of dornase alfa. It is a man-made version of a protein found in your body called ‘DNase’.

 

Pulmozyme is used for people with cystic fibrosis. It helps by breaking down the thick mucus found in lungs. This helps lungs of people with cystic fibrosis to work better. Pulmozyme is breathed in (inhaled) using something called a nebulizer.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Pulmozyme 2500 U/2.5ml Nebuliser Solution

Roaccutane is used to treat patients with severe forms of acne.

 

Roaccutane is a tablet which contains active ingredient of isotretinoin – a substance related to vitamin A, and one of a group of medicines called retinoids (for treatment of acne).

 

Retinoids work by reducing the amount of the oily substance (i.e. sebum) made by glands in your skin, reducing bacteria and inflammation and opening clogged pores.

 

Therapy should be supervised by a dermatologist. Roaccutane is a possible teratogen (an agent or factor which causes malformation of an embryo). Female patients should be on the pregnancy prevention program whilst on Roaccutane therapy.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Roaccutane 10mg Capsules
Patient Information Leaflet - Roaccutane 20mg Capsules

RoACTEMRA is used to treat moderate-to-severe Rheumatoid Arthritis in adults, systemic juvenile idiopathic arthritis (sJIA), juvenile idiopathic polyarthritis (pJIA) in children, and Giant Cell Arteritis (GCA) in adults.

 

RoACTEMRA (tocilizumab) contains the active substance tocilizumab which is a protein made from specific immune cells that blocks the action of a specific protein cytokine called interleukin-6 (IL-6). IL-6 is believed to play a key role in activating the inflammatory pathway that contributes to the signs and symptoms of RA and other inflammatory autoimmune conditions. RoActemra (tocilizumab) binds to IL-6 receptors, blocking the pro-inflammatory effect of IL-6 cytokines.

 

RoActemra (tocilizumab) is available in both subcutaneous (SC) and intravenous (IV) formulations.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - RoActemra 20 mg/ml concentrate for solution for infusion.

Patient Information Leaflet - RoActemra 162 mg solution for injection in pre-filled syringe

Patient Information Leaflet - RoActemra 162 mg solution for injection in pre-filled pen

 

Rocephin is an antibiotic given to adults and children intravenously (IV) by infusion or by injection (including newborn babies). It contains the active ingredient ceftraxione and works by killing bacteria that cause infections.

 

It belongs to a group of medicines called cephalosporins. Rocephin is administered by injection into a muscle in a solution containing lidocaine, which reduces the pain associated with the injection.

It can be given: to treat specific sexually transmitted infections (gonorrhoea and syphilis), to treat patients with low white blood cell counts (neutropenia) who have fever due to bacterial infection, to treat infections of the chest in adults with chronic bronchitis and to treat Lyme disease (caused by tick bites) in adults and children including newborn babies from 15 days of age.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Rocephin 1g Powder and Solvent for IM Injection.

Patient Information Leaflet - Rocephin 1g Powder for Solution for Injection or Infusion.

Rozlytrek is a medicine, used for the treatment of adult and paediatric patients 12 years of age and older with solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion. Who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor, who have no satisfactory treatment options. Rozlytrek is also, used for the treatment of adult patients with ROS1-positive, advanced non-small cell lung cancer (NSCLC) not previously treated with ROS1 inhibitor.

 

Rozlytrek contains the active substance entrectinib and is a targeted therapy called a kinase inhibitor. It works by blocking the action of abnormal enzymes caused by a change in the NTRK or ROS1 genes that make them. The faulty enzymes encourage the cancer cells to grow.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Rozlytrek 100 mg and 200 mg hard capsules

Tamiflu is used for the prevention and treatment of influenza.

 

Tamiflu contains the active ingredient oseltamivir, it is an oral anti-viral agent which belongs to a group of medicines named neuraminidase inhibitors.

 

Tamiflu binds to the neuraminidase on the surface of the virus particles and hence inhibits the new viral particles' chemical ability to escape from the infected cell. The influenza virus is thereby restricted to a smaller number of cells and the body's immune system has a better chance of killing the virus.

 

Tamiflu helps to ease or prevent the symptoms of the flu virus infection.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Tamiflu 30 mg Hard Capsules
Patient Information Leaflet - Tamiflu 45 mg Hard Capsules
Patient Information Leaflet - Tamiflu 75 mg Hard Capsules
Patient Information Leaflet - Tamiflu 6 mg/ml Powder for Oral Suspension

Tarceva is used for the treatment of patients with lung and pancreatic cancer.

 

Tarceva is a tablet that contains the active substance erlotinib. It belongs to a group of drug called tyrosine kinase inhibitors.

 

Tarceva is a medicine used to treat cancer by preventing the activity of a protein called epidermal growth factor receptor (EGFR). This protein is known to be involved in the growth and spread of cancer cells.  When the ECFR protein has certain types of genetic mutations, Tarceva can interfere with these signals. This may cause the cancer cells to die.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Tarceva 25mg, 100mg and 150mg Film-Coated Tablets

Tecentriq is used to treat certain types of cancers that affect the lungs called non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (ES-SCLC). It is also used to treat a cancer that affects the bladder and the urinary system, called urothelial carcinoma (UC), along with specific type of breast cancer called triple negative breast cancer (TNBC) and hepatocellular carcinoma (HCC), which is a type cancer that affects the liver.

 

Tecentriq is a monoclonal antibody that contains active substance atezolizumab. A monoclonal antibody is a type of protein designed to recognise and attach to a specific target in the body. It is a type of medication called immunotherapy.

 

Tecentriq works by attaching to a specific protein in your body called programmed death-ligand 1 (PD-L1). This protein suppresses the body's immune (defence) system, thereby protecting cancer cells from being attacked by the immune cells. By attaching to the protein, Tecentriq helps your immune system to fight your cancer.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Tecentriq 1,200 mg concentrate for solution for infusion (NSCLC, ES-SCLC, UC, HCC)

Patient Information Leaflet - Tecentriq 840 mg concentrate for solution for infusion (NSCLC, UC, TNBC)

Valcyte is used for the prevention of cytomegalovirus (CMV) infections in kidney, heart, and pancreas transplant patients. Also used in the treatment of CMV retinitis in patients with AIDS.

Valcyte is a tablet or oral solution that contains the active ingredient called valganciclovir. It belongs to a group of medicines called valganciclovir which work directly to prevent the growth of viruses. In the body the active ingredient in the tablets, valganciclovir, is changed into ganciclovir. Ganciclovir prevents a virus called cytomegalovirus (CMV) from multiplying and invading healthy cells.

In patients with a weakened immune system, CMV can cause an infection in the body’s organs. This can be life threatening.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Valcyte 450mg film-coated tablets.

Patient Information Leaflet - Valcyte 50mg/ml powder for oral solution.

Zelboraf is for the treatment of patients with metastatic melanoma with BRAF V600 mutation.

Zelboraf is an anticancer medicine that contains the active substance vemurafenib. It belongs to a group of drugs called small molecule kinase inhibitors.

It is used to treat adult patients with melanoma that has spread to other parts of the body or cannot be removed by surgery. It can only be used in patients whose cancer has a change (mutation) in the “BRAF” gene - BRAF V600 mutations. This change may have led to the development of melanoma. Zelboraf targets proteins made from this modified gene and slows down or stops the development of the cancer.

Patient Information Leaflet (PIL)

This link will take you to www.medicines.ie which is a non-Roche website.

Patient Information Leaflet - Zelboraf 240mg Film-coated Tablets